This project consists in developing the next generation high-fidelity connectome framework that encompasses a tailored brain data representation as a large-scale directed graph, capturing direction-specific eletrical conductivity, axonal count estimates and other microstructural features, both locally in the white matter and with cortex-to-cortex integration.
Project pageDouble diffusion encoding and white matter structure with 3T, 7T and latest reconstruction and post-processing
New model to link effectively conduction delays and fiber tract characteristics.
Electrical souce activity of local gray matter reconstructed with unprecedent accuray and signal-to-noise ration from high density EEG thanks to encompassed priors based on connectome sparsity and brain morphology
Fast dynamics of electricral activity on the high-fidelity connectome will be analyzed with advanced and tailored methods namely directed graph signal processing, joint vertex-time graph signal processing ant time-varying frequency-specific directed functional connectivity (Granger modeling)
The precision neuroimaging framework will be clinically applied to focal epilepsy. Pathological brain activity and network dynamics will be localized in intericral and ictal states. This will improve our understanding of the patho- physiology and help to identify subject-specific biomarkers for diagnostic stratification and treatment response.
Institutions
Countries
